#endothelial function

2 articles

Approach: human outcome. Palette: natural.

Close, low-angle shot of an older adult's bare lower leg and bare feet resting on crisp white hospital bed linen, with a soft, out-of-focus window in the background. The camera sits at mattress level and looks along the calf toward the ankle. Face is not visible. A small ultrasound probe coated in clear gel presses against the back of the knee. The operator's gloved hand enters from the frame edge. Soft overcast daylight from the window gives skin tones a warm, realistic look. Around the bed, a sprig of fresh rosemary and a few purple-green ashwagandha leaves sit on a wooden bedside tray. The leaves provide plant-green accents, along with one small electric green sensor light on a monitor. Palette: natural greens, wood browns and warm skin. Mood: quiet, careful and hopeful.

PB125: Biljni Nrf2 miks koji je očuvao rad arterija tokom odmora u krevetu

BY NOVA CHEN · 31. окт 2026.

Biljni aktivator Nrf2 pod imenom PB125, sa sastavom od ruzmarina, ashwagandhe i luteolina, testiran je u malom, dvostruko‑slepom ljudskom ispitivanju. Kod 24 starija učesnika, dve nedelje suplementacije dozom od 200 mg dnevno podigla je brahijalni FMD sa 2,8 % na 3,8 % i poplitealni FMD sa 1,5 % na 2,3 %. Tokom pet dana odmora u krevetu, mešavina je očuvala funkciju arterija i nivoe antioksidativnih enzima u poređenju sa placebo grupom. Kod mlađih odraslih nije zabeležen početni porast FMD, iako je PB125 zaštitio poplitealni FMD tokom imobilizacije. Sa samo 44 učesnika i surrogatnim ishodima, ovo je obećavajući signal, a ne čvrst dokaz kliničke koristi.

**Approach:** Conceptual metaphor, in a bold color field palette (D).

A single ripe pomegranate, split open, on a saturated teal backdrop. It is the natural source of urolithin A's precursors. The camera sits at a slightly low three-quarter angle, close enough to show glossy, translucent arils. On the left half, the arils sit dull and tightly packed. On the right, a few arils hold a faint electric green glow, as if lit from within, hinting at a selective response in one place and not another. Behind the fruit, a thin copper wire runs across the frame and is unbroken on one side and fraying on the other, standing for arteries versus brain vessels. Soft, directional studio light from the upper left casts crisp shadows. Mood: curious, restrained, quietly hopeful. No text anywhere.

supplements

Urolitin A nije popravio arterije za 4 nedelje, ali je mozak reagovao

BY NOVA CHEN · 26. окт 2026.

Dvostruko slepa studija na 50 odraslih osoba, starosti 40–64 godine, sa gojaznošću, pokazala je da doza od 1.000 mg urolitina A dnevno tokom četiri nedelje nije poboljšala protokom‑zavisnu dilataciju (FMD), glavni cilj istraživanja. Periferni mikrovaskularni parametri takođe su ostali nepromenjeni. Međutim, hemodinamički odgovori mozga na kognitivni zadatak bili su značajno veći kod onih koji su uzimali urolitin A, iako se performanse zadatka nisu promenile. Pošto je ova pojava sekundarna i potekla iz kratke, male studije, predstavlja smernicu, a ne konačan zaključak. Evo šta podaci pokazuju, šta ne pokazuju i šta to znači za sve koji razmišljaju o suplementu.